Synthesis of (-)-Reidispongiolide A

doi:10.1055/s-2007-992394

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Synfacts 2008(1): 0007-0007
DOI: 10.1055/s-2007-992394

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Reidispongiolide A

Contributor(s): Philip Kocienski
I. Paterson*, K. Ashton, R. Britton, G. Cecere, G. Chouraqui, G. J. Florence, J. Stafford
University of Cambridge, UK

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Publication History

Publication Date:
18 December 2007 (online)

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Significance

Reidispongiolide A is a sponge (Reidispongia coerulea) metabolite whose interaction with actin leads to microfilament destabilization and consequent antiproliferative activity. The first total synthesis of reidispongiolide A is based largely on boron-mediated aldol condensations.